When you’re feeling under the weather, nothing beats a warm bowl of Italian Penicillin Soup. This nourishing dish is packed with immune-boosting ingredients like garlic, onions, oregano, and chicken, making it a staple in traditional Italian households. More than just comfort food, this soup is known for its healing properties, helping to soothe colds, fight infections, and provide essential nutrients for recovery.

Throughout history, cultures worldwide have relied on chicken soup for its restorative benefits. The classic version, often called “Jewish penicillin”, has been widely recognized for its role in easing cold symptoms. However, the Italian variation adds a Mediterranean twist with herbs, tomatoes, and nutrient-dense greens, enhancing both flavor and nutritional value. According to Wikipedia’s entry on chicken soup, its popularity as a home remedy spans centuries, proving its effectiveness across different cuisines.

What makes Italian Penicillin Soup so powerful is its combination of natural ingredients that work together to support the immune system. From the antimicrobial properties of garlic to the anti-inflammatory benefits of oregano, each component plays a crucial role in promoting overall health. If you’re interested in learning more about herbal remedies, you can explore their effects in herbal medicine.

Whether you’re battling a cold, looking for a nutrient-packed meal, or simply craving a bowl of warm, flavorful comfort, this traditional Italian soup is a must-try. In the following sections, we’ll explore why it’s called “penicillin soup”, its key health benefits, and how you can make it at home for an instant immune boost.

Why Is It Called “Penicillin Soup”?

The name Italian Penicillin Soup comes from its reputation as a natural remedy for colds, flu, and other minor illnesses. Just like traditional chicken soup, this version is believed to have healing properties that help the body recover faster. But what makes it comparable to penicillin, the famous antibiotic?

Garlic: Nature’s Antibiotic – One of the key ingredients, garlic, contains allicin, a compound known for its antibacterial and antiviral properties. According to Wikipedia, garlic has been used for centuries as a natural medicine to fight infections and boost immunity.
Chicken Broth for Healing – Homemade chicken broth is packed with collagen, amino acids, and minerals, which help reduce inflammation and support the body’s natural healing process. Learn how to make a rich and nourishing broth from this Pinterest guide on homemade chicken broth.
Herbs with Medicinal Properties – The addition of oregano, basil, and red pepper flakes gives this soup an extra anti-inflammatory and antimicrobial boost. Oregano, for example, has been studied for its antibacterial effects, which you can read more about here.

The term penicillin soup has been widely used for various healing soups, but this Italian version stands out due to its Mediterranean ingredients. These components not only help clear congestion and soothe sore throats, but they also provide the body with essential vitamins, minerals, and antioxidants for faster recovery.

In the next section, we’ll take a deeper look at how each key ingredient plays a role in boosting immunity and fighting illness.

Immune-Boosting Benefits of Key Ingredients

The power of Italian Penicillin Soup lies in its nutrient-rich ingredients, each offering unique health benefits. From garlic’s antibacterial properties to leafy greens packed with vitamins, this soup is designed to strengthen the immune system and aid recovery. Let’s break down the health benefits of each key ingredient.

1. Chicken Broth – A Healing Base

A warm bowl of chicken broth is more than just comforting—it’s packed with essential nutrients that support immune function.

Contains collagen and amino acids, which help repair the gut lining and reduce inflammation.
Rich in minerals like calcium, magnesium, and phosphorus, essential for immune health.
Acts as a natural decongestant, helping to clear nasal passages and soothe sore throats.
Learn more about the benefits of chicken soup and why it’s considered a natural remedy for colds.

2. Garlic – Nature’s Antibiotic

Garlic is one of the most powerful natural antibiotics found in food.

Contains allicin, a compound with strong antibacterial, antiviral, and antifungal properties.
Helps fight respiratory infections and speeds up recovery from colds and flu.
According to Wikipedia, garlic has been used medicinally for thousands of years due to its immune-boosting effects.

3. Onions & Celery – Rich in Antioxidants

Both onions and celery contribute to the soup’s anti-inflammatory and detoxifying effects.

Onions contain quercetin, a flavonoid known for its antiviral and antihistamine properties.
Celery is high in vitamin C and potassium, helping to flush toxins from the body.
Together, these ingredients aid in reducing mucus buildup and supporting respiratory health.

4. Carrots & Tomatoes – Vitamin-Packed Superfoods

These vegetables provide a natural vitamin C and beta-carotene boost, essential for immune function.

Carrots are high in beta-carotene, which converts into vitamin A, crucial for immune system support.
Tomatoes are rich in lycopene, a powerful antioxidant that reduces inflammation and oxidative stress.
For more recipes featuring immunity-boosting foods, check out this Pinterest board.

5. Spinach & Kale – Nutrient-Dense Greens

Adding spinach or kale enhances the soup’s nutritional profile with iron, vitamin K, and antioxidants.

High in folate and vitamin C, which help stimulate white blood cell production.
Loaded with phytonutrients that reduce inflammation and promote cell repair.
Read more about the benefits of a Mediterranean diet, which emphasizes leafy greens for optimal health.

6. Oregano & Basil – Anti-Inflammatory Herbs

Herbs like oregano and basil don’t just add flavor—they’re packed with medicinal benefits.

Oregano has antibacterial and antimicrobial properties, making it a natural defense against infections. Learn more about oregano’s healing properties.
Basil contains eugenol, a compound that helps reduce inflammation and support respiratory health.

7. Crushed Red Pepper Flakes – A Natural Decongestant

If you’re feeling congested, red pepper flakes can provide instant relief.

Contains capsaicin, which helps clear nasal passages and reduce mucus buildup.
Boosts circulation and metabolism, aiding in faster recovery from colds.

This combination of nutrient-dense ingredients makes Italian Penicillin Soup one of the best natural remedies for colds and flu. In the next section, we’ll go step by step through the cooking process so you can make this immune-boosting soup at home.

How to Make Italian Penicillin Soup (Step-by-Step Guide)

This simple yet flavorful recipe brings together nutrient-rich ingredients to create a healing, immune-boosting soup. Follow this step-by-step guide to prepare the perfect bowl of Italian Penicillin Soup.

Ingredients You’ll Need

To make this comforting, cold-fighting soup, gather the following ingredients:

1 tablespoon olive oil – Adds richness and enhances flavor.
1 small onion, diced – Provides antioxidants and supports respiratory health.
2 cloves garlic, minced – Acts as a natural antibiotic.
2 carrots, sliced – High in beta-carotene for immune support.
2 celery stalks, chopped – Contains anti-inflammatory properties.
6 cups chicken broth – The foundation of this healing soup. Learn more about making homemade broth.
2 cups cooked shredded chicken – A lean protein that aids recovery.
1 can (14.5 oz) diced tomatoes – Packed with vitamin C and antioxidants.
1 teaspoon dried oregano – A powerful antimicrobial herb. Discover oregano’s health benefits.
1 teaspoon dried basil – Enhances flavor and promotes respiratory health.
½ teaspoon crushed red pepper flakes (optional) – Helps clear congestion.
1 cup small pasta (such as ditalini or orzo) – Adds texture and makes the soup more filling.
2 cups fresh spinach or kale, chopped – Provides essential vitamins and minerals.
Salt and pepper to taste – Balances flavors.
Freshly grated Parmesan cheese for serving – Optional, but adds richness.

Step-by-Step Instructions

Step 1: Sauté the Aromatics

Heat olive oil in a large pot over medium heat.
Add diced onion, garlic, carrots, and celery. Sauté for about 5 minutes until softened and fragrant.

Step 2: Add Broth and Simmer

Pour in the chicken broth and bring it to a gentle simmer.
Stir in the shredded chicken, diced tomatoes, oregano, basil, and red pepper flakes (if using).
Let it simmer for 10 minutes, allowing the flavors to meld.

Step 3: Cook the Pasta

Add pasta and cook until tender, about 8-10 minutes.
Stir occasionally to prevent sticking.

Step 4: Add Leafy Greens

Stir in chopped spinach or kale and cook for another 2 minutes, until wilted.

Step 5: Season and Serve

Taste and adjust salt and pepper as needed.
Ladle the soup into bowls and garnish with freshly grated Parmesan cheese.
Serve warm with a slice of crusty Italian bread or garlic toast. Find more comfort food pairings.

Variations & Substitutions

1. Vegetarian/Vegan Option

Replace chicken broth with vegetable broth.
Swap shredded chicken for chickpeas or white beans for plant-based protein.

2. Gluten-Free Option

Use gluten-free pasta or replace it with quinoa or rice.

3. Low-Carb/Keto Version

Omit the pasta and add zucchini noodles or extra veggies instead.

4. Spicy Version

Increase red pepper flakes or add fresh chili peppers for extra heat.

5. Creamy Version

Stir in heavy cream or coconut milk for a richer texture.

Explore more healthy soup recipes to customize this dish to your taste.

Best Serving Suggestions

Pair with crusty Italian bread, garlic toast, or a fresh green salad.
Top with Parmesan, Pecorino Romano, or mozzarella for extra richness.
Serve as a starter or a main dish with a side of roasted vegetables.

For more traditional Italian recipes, check out this collection.

Storage & Meal Prep Tips

Refrigeration

Store leftovers in an airtight container in the fridge for 3-4 days.

Freezing Instructions

Freeze in portioned containers for up to 3 months.
For best results, freeze without pasta, then add fresh pasta when reheating.

Reheating Tips

Warm on the stovetop over low heat, adding extra broth if needed.
If reheating from frozen, let it thaw overnight in the refrigerator before reheating.

Frequently Asked Questions (FAQs)

1. Can I use rotisserie chicken for this soup?

Yes! Rotisserie chicken is a great time-saving option. Simply shred the cooked meat and add it to the broth.

2. What’s the best pasta type for this recipe?

Small pasta shapes like ditalini, orzo, or pastina work best because they absorb the broth without overpowering the soup.

3. How can I make this soup even more nutritious?

Add extra veggies like bell peppers, mushrooms, or zucchini. You can also stir in turmeric or ginger for an extra anti-inflammatory boost.

4. Can I make this in a slow cooker or Instant Pot?

Absolutely!

Slow Cooker: Sauté the aromatics first, then add all ingredients (except pasta and greens) and cook on low for 6-8 hours or high for 3-4 hours. Stir in pasta and greens 15 minutes before serving.
Instant Pot: Use the sauté function for aromatics, then add all ingredients (except pasta and greens). Cook on high pressure for 10 minutes, quick release, then stir in pasta and greens.

5. What’s the best way to store leftovers?

Store in the refrigerator for up to 4 days or freeze for long-term storage.
Keep pasta separate if freezing to prevent it from becoming mushy.

Italian Penicillin Soup